Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells

Maintenance of immune homeostasis requires regulatory T (T(reg)) cells. Here we show that T(reg)-specific ablation of Ubc13, a lysine 63-specific ubiquitin-conjugating enzyme, caused aberrant T cell activation and autoimmunity. Although Ubc13 deficiency did not affect T(reg) cell survival or Foxp3 e...

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Detalles Bibliográficos
Autores principales: Chang, Jae-Hoon, Xiao, Yichuan, Hu, Hongbo, Jin, Jin, Yu, Jiayi, Zhou, Xiaofei, Wu, Xuefeng, Johnson, Howard M, Akira, Shizuo, Pasparakis, Manolis, Cheng, Xuhong, Sun, Shao-Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361639/
https://www.ncbi.nlm.nih.gov/pubmed/22484734
http://dx.doi.org/10.1038/ni.2267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361639/
https://www.ncbi.nlm.nih.gov/pubmed/22484734
http://dx.doi.org/10.1038/ni.2267

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