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Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells
Maintenance of immune homeostasis requires regulatory T (T(reg)) cells. Here we show that T(reg)-specific ablation of Ubc13, a lysine 63-specific ubiquitin-conjugating enzyme, caused aberrant T cell activation and autoimmunity. Although Ubc13 deficiency did not affect T(reg) cell survival or Foxp3 e...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361639/ https://www.ncbi.nlm.nih.gov/pubmed/22484734 http://dx.doi.org/10.1038/ni.2267 |