Biophysical Characterization of the Strong Stabilization of the RNA Triplex poly(U)(•)poly(A)(*)poly(U) by 9-O-(ω-amino) Alkyl Ether Berberine Analogs

BACKGROUND: Binding of two 9-O-(ω-amino) alkyl ether berberine analogs BC1 and BC2 to the RNA triplex poly(U)(•)poly(A)(*)poly(U) was studied by various biophysical techniques. METHODOLOGY/PRINCIPAL FINDINGS: Berberine analogs bind to the RNA triplex non-cooperatively. The affinity of binding was re...

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Detalles Bibliográficos
Autores principales: Bhowmik, Debipreeta, Das, Suman, Hossain, Maidul, Haq, Lucy, Suresh Kumar, Gopinatha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362543/
https://www.ncbi.nlm.nih.gov/pubmed/22666416
http://dx.doi.org/10.1371/journal.pone.0037939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362543/
https://www.ncbi.nlm.nih.gov/pubmed/22666416
http://dx.doi.org/10.1371/journal.pone.0037939

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