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Biophysical Characterization of the Strong Stabilization of the RNA Triplex poly(U)(•)poly(A)(*)poly(U) by 9-O-(ω-amino) Alkyl Ether Berberine Analogs
BACKGROUND: Binding of two 9-O-(ω-amino) alkyl ether berberine analogs BC1 and BC2 to the RNA triplex poly(U)(•)poly(A)(*)poly(U) was studied by various biophysical techniques. METHODOLOGY/PRINCIPAL FINDINGS: Berberine analogs bind to the RNA triplex non-cooperatively. The affinity of binding was re...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362543/ https://www.ncbi.nlm.nih.gov/pubmed/22666416 http://dx.doi.org/10.1371/journal.pone.0037939 |