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Studies on the Restriction of Murine Leukemia Viruses by Mouse APOBEC3

APOBEC3 proteins function to restrict the replication of retroviruses. One mechanism of this restriction is deamination of cytidines to uridines in (−) strand DNA, resulting in hypermutation of guanosines to adenosines in viral (+) strands. However, Moloney murine leukemia virus (MoMLV) is partially...

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Detalles Bibliográficos
Autores principales: Sanchez-Martinez, Silvia, Aloia, Amanda L., Harvin, Demetria, Mirro, Jane, Gorelick, Robert J., Jern, Patric, Coffin, John M., Rein, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362552/
https://www.ncbi.nlm.nih.gov/pubmed/22666481
http://dx.doi.org/10.1371/journal.pone.0038190