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Tumour Cell Generation of Inducible Regulatory T-Cells in Multiple Myeloma Is Contact-Dependent and Antigen-Presenting Cell-Independent

Regulatory T-cells (T(Reg) cells) are increased in patients with multiple myeloma (MM). We investigated whether MM cells could generate and/or expand T(Reg) cells as a method of immuno-surveillance avoidance. In an in vitro model, CD4(+)CD25(-) FoxP3 (-) T-cells co-cultured with malignant plasma cel...

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Detalles Bibliográficos
Autores principales:	Feyler, Sylvia, Scott, Gina B., Parrish, Christopher, Jarmin, Sarah, Evans, Paul, Short, Mike, McKinley, Katherine, Selby, Peter J., Cook, Gordon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362588/ https://www.ncbi.nlm.nih.gov/pubmed/22666318 http://dx.doi.org/10.1371/journal.pone.0035981

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