Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

Clonal deletion of autoreactive thymocytes is important for self-tolerance, but the intra-thymic signals that induce clonal deletion have not been clearly identified. We now report that clonal deletion during negative selection requires CD28 costimulation of autoreactive thymocytes at the CD4(+)CD8(...

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Detalles Bibliográficos
Autores principales: Pobezinsky, Leonid A., Angelov, Georgi S., Tai, Xuguang, Jeurling, Susanna, Van Laethem, François, Feigenbaum, Lionel, Park, Jung-Hyun, Singer, Alfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362677/
https://www.ncbi.nlm.nih.gov/pubmed/22544394
http://dx.doi.org/10.1038/ni.2292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362677/
https://www.ncbi.nlm.nih.gov/pubmed/22544394
http://dx.doi.org/10.1038/ni.2292

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