Cargando…
Clonal deletion and the fate of autoreactive thymocytes that survive negative selection
Clonal deletion of autoreactive thymocytes is important for self-tolerance, but the intra-thymic signals that induce clonal deletion have not been clearly identified. We now report that clonal deletion during negative selection requires CD28 costimulation of autoreactive thymocytes at the CD4(+)CD8(...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362677/ https://www.ncbi.nlm.nih.gov/pubmed/22544394 http://dx.doi.org/10.1038/ni.2292 |