Non-classical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum

The ER aminopeptidase associated with antigen processing, ERAAP, is essential for trimming peptides presented by MHC I molecules. ERAAP inhibition by cytomegalovirus causes immune evasion, and ERAAP polymorphisms are associated with autoimmune disorders. How normal ERAAP function is monitored is unk...

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Detalles Bibliográficos
Autores principales: Nagarajan, Niranjana A., Gonzalez, Federico, Shastri, Nilabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362685/
https://www.ncbi.nlm.nih.gov/pubmed/22522492
http://dx.doi.org/10.1038/ni.2282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362685/
https://www.ncbi.nlm.nih.gov/pubmed/22522492
http://dx.doi.org/10.1038/ni.2282

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