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Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injury

BACKGROUND: Stimulation of epithelial sodium channel (ENaC) increases Na(+ )transport, a driving force of alveolar fluid clearance (AFC) to keep alveolar spaces free of edema fluid that is beneficial for acute lung injury (ALI). It is well recognized that regulation of ENaC by insulin via PI3K pathw...

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Detalles Bibliográficos
Autores principales: Deng, Wang, Li, Chang-Yi, Tong, Jin, Zhang, Wei, Wang, Dao-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362779/
https://www.ncbi.nlm.nih.gov/pubmed/22458687
http://dx.doi.org/10.1186/1465-9921-13-29