DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription

Disrupted-In-Schizophrenia 1 (DISC1), a strong genetic candidate for psychiatric illness, encodes a multicompartmentalized molecular scaffold that regulates interacting proteins with key roles in neurodevelopment and plasticity. Missense DISC1 variants are associated with the risk of mental illness...

Descripción completa

Detalles Bibliográficos
Autores principales: Malavasi, Elise L.V., Ogawa, Fumiaki, Porteous, David J., Millar, J. Kirsty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363331/
https://www.ncbi.nlm.nih.gov/pubmed/22422769
http://dx.doi.org/10.1093/hmg/dds106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363331/
https://www.ncbi.nlm.nih.gov/pubmed/22422769
http://dx.doi.org/10.1093/hmg/dds106

Ejemplares similares