Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer

BACKGROUND: MicroRNA-143 (miRNA-143) is frequently down-regulated in colorectal cancer (CRC) and may influence CRC cell proliferation, apoptosis and sensitivity to 5-fluorouracil. mRNA encoded by the KRAS oncogene has been identified as a target of miRNA-143. However, the prognostic significance of...

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Detalles Bibliográficos
Autores principales: Pichler, M, Winter, E, Stotz, M, Eberhard, K, Samonigg, H, Lax, S, Hoefler, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364114/
https://www.ncbi.nlm.nih.gov/pubmed/22549179
http://dx.doi.org/10.1038/bjc.2012.175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364114/
https://www.ncbi.nlm.nih.gov/pubmed/22549179
http://dx.doi.org/10.1038/bjc.2012.175

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