Contrasting effects of diclofenac and ibuprofen on active imatinib uptake into leukaemic cells

BACKGROUND: The human organic cation transporter-1 (OCT-1) is the primary active protein for imatinib uptake into target BCR-ABL-positive cells. Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used by chronic myeloid leukaemia (CML) patients on imatinib to manage musculoskeletal compla...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, J, Hughes, T P, Kok, C H, Saunders, V A, Frede, A, Groot-Obbink, K, Osborn, M, Somogyi, A A, D'Andrea, R J, White, D L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364120/
https://www.ncbi.nlm.nih.gov/pubmed/22531634
http://dx.doi.org/10.1038/bjc.2012.173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364120/
https://www.ncbi.nlm.nih.gov/pubmed/22531634
http://dx.doi.org/10.1038/bjc.2012.173

Ejemplares similares