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Contrasting effects of diclofenac and ibuprofen on active imatinib uptake into leukaemic cells

BACKGROUND: The human organic cation transporter-1 (OCT-1) is the primary active protein for imatinib uptake into target BCR-ABL-positive cells. Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used by chronic myeloid leukaemia (CML) patients on imatinib to manage musculoskeletal compla...

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Detalles Bibliográficos
Autores principales:	Wang, J, Hughes, T P, Kok, C H, Saunders, V A, Frede, A, Groot-Obbink, K, Osborn, M, Somogyi, A A, D'Andrea, R J, White, D L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364120/ https://www.ncbi.nlm.nih.gov/pubmed/22531634 http://dx.doi.org/10.1038/bjc.2012.173

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