A High Throughput Screen Identifies Nefopam as Targeting Cell Proliferation in β-Catenin Driven Neoplastic and Reactive Fibroproliferative Disorders

Fibroproliferative disorders include neoplastic and reactive processes (e.g. desmoid tumor and hypertrophic scars). They are characterized by activation of β-catenin signaling, and effective pharmacologic approaches are lacking. Here we undertook a high throughput screen using human desmoid tumor ce...

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Detalles Bibliográficos
Autores principales: Poon, Raymond, Hong, Helen, Wei, Xin, Pan, James, Alman, Benjamin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364163/
https://www.ncbi.nlm.nih.gov/pubmed/22666417
http://dx.doi.org/10.1371/journal.pone.0037940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364163/
https://www.ncbi.nlm.nih.gov/pubmed/22666417
http://dx.doi.org/10.1371/journal.pone.0037940

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