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NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains
Metastatic cells are highly plastic for differential expression of tumor phenotype hallmarks and metastatic organotropism. The signaling proteins orchestrating the shift of one cell phenotype and organ pattern to another are little known. Na(+)/H(+) exchanger regulatory factor (NHERF1) is a molecula...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364169/ https://www.ncbi.nlm.nih.gov/pubmed/22496422 http://dx.doi.org/10.1091/mbc.E11-11-0911 |