Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness

Hereditary myosin myopathies are characterized by variable clinical features. Inclusion body myopathy 3 (IBM-3) is an autosomal dominant disease associated with a missense mutation (E706K) in the myosin heavy chain IIa gene. Adult patients experience progressive muscle weakness. Biopsies reveal dyst...

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Detalles Bibliográficos
Autores principales: Wang, Yang, Melkani, Girish C., Suggs, Jennifer A., Melkani, Anju, Kronert, William A., Cammarato, Anthony, Bernstein, Sanford I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364171/
https://www.ncbi.nlm.nih.gov/pubmed/22496423
http://dx.doi.org/10.1091/mbc.E12-02-0120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364171/
https://www.ncbi.nlm.nih.gov/pubmed/22496423
http://dx.doi.org/10.1091/mbc.E12-02-0120

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