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Lamin B1 loss is a senescence-associated biomarker

Cellular senescence is a potent tumor-suppressive mechanism that arrests cell proliferation and has been linked to aging. However, studies of senescence have been impeded by the lack of simple, exclusive biomarkers of the senescent state. Senescent cells develop characteristic morphological changes,...

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Detalles Bibliográficos
Autores principales: Freund, Adam, Laberge, Remi-Martin, Demaria, Marco, Campisi, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364172/
https://www.ncbi.nlm.nih.gov/pubmed/22496421
http://dx.doi.org/10.1091/mbc.E11-10-0884