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Fractionation of a Herbal Antidiarrheal Medicine Reveals Eugenol as an Inhibitor of Ca(2+)-Activated Cl(−) Channel TMEM16A

The Ca(2+)-activated Cl(−) channel TMEM16A is involved in epithelial fluid secretion, smooth muscle contraction and neurosensory signaling. We identified a Thai herbal antidiarrheal formulation that inhibited TMEM16A Cl(−) conductance. C18-reversed-phase HPLC fractionation of the herbal formulation...

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Detalles Bibliográficos
Autores principales:	Yao, Zhen, Namkung, Wan, Ko, Eun A., Park, Jinhong, Tradtrantip, Lukmanee, Verkman, A. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364195/ https://www.ncbi.nlm.nih.gov/pubmed/22666439 http://dx.doi.org/10.1371/journal.pone.0038030

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