Genome-Wide Characterization of Menin-Dependent H3K4me3 Reveals a Specific Role for Menin in the Regulation of Genes Implicated in MEN1-Like Tumors

Inactivating mutations in the MEN1 gene predisposing to the multiple endocrine neoplasia type 1 (MEN1) syndrome can also cause sporadic pancreatic endocrine tumors. MEN1 encodes menin, a subunit of MLL1/MLL2-containing histone methyltransferase complexes that trimethylate histone H3 at lysine 4 (H3K...

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Detalles Bibliográficos
Autores principales: Agarwal, Sunita K., Jothi, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364203/
https://www.ncbi.nlm.nih.gov/pubmed/22666422
http://dx.doi.org/10.1371/journal.pone.0037952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364203/
https://www.ncbi.nlm.nih.gov/pubmed/22666422
http://dx.doi.org/10.1371/journal.pone.0037952

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