Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans

The objectives of this study were (i) to develop a screening-level Quantitative property-property relationship (QPPR) for intrinsic clearance (CL(int)) obtained from in vivo animal studies and (ii) to incorporate it with human physiology in a PBPK model for predicting the inhalation pharmacokinetics...

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Detalles Bibliográficos
Autores principales: Peyret, Thomas, Krishnan, Kannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364689/
https://www.ncbi.nlm.nih.gov/pubmed/22685458
http://dx.doi.org/10.1155/2012/286079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364689/
https://www.ncbi.nlm.nih.gov/pubmed/22685458
http://dx.doi.org/10.1155/2012/286079

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