Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin

Canonical Wnt signalling requires caveolin-dependent internalization of low-density lipoprotein receptor-related protein 6 (LRP6). Here we report that the tumour suppressor and endocytic adaptor disabled-2 (Dab2), previously described as an inhibitor of Wnt/β-catenin signalling, selectively recruits...

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Detalles Bibliográficos
Autores principales: Jiang, Yong, He, Xi, Howe, Philip H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364753/
https://www.ncbi.nlm.nih.gov/pubmed/22491013
http://dx.doi.org/10.1038/emboj.2012.83

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364753/
https://www.ncbi.nlm.nih.gov/pubmed/22491013
http://dx.doi.org/10.1038/emboj.2012.83

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