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Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?

BACKGROUND: RRM1 and ERCC1 overexpression has been extensively investigated as potential predictive markers of tumor sensitivity to conventional chemotherapy agents, most thoroughly in lung cancer. However, data in pancreatic cancer are scarce. METHODS: We investigated the mRNA and protein expressio...

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Detalles Bibliográficos
Autores principales: Valsecchi, Matias E, Holdbrook, Thomas, Leiby, Benjamin E, Pequignot, Edward, Littman, Susan J, Yeo, Charles J, Brody, Jonathan R, Witkiewicz, Agnieszka K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364898/
https://www.ncbi.nlm.nih.gov/pubmed/22436573
http://dx.doi.org/10.1186/1471-2407-12-104