General Anesthetics Predicted to Block the GLIC Pore with Micromolar Affinity

Although general anesthetics are known to modulate the activity of ligand-gated ion channels in the Cys-loop superfamily, there is at present neither consensus on the underlying mechanisms, nor predictive models of this modulation. Viable models need to offer quantitative assessment of the relative...

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Detalles Bibliográficos
Autores principales: LeBard, David N., Hénin, Jérôme, Eckenhoff, Roderic G., Klein, Michael L., Brannigan, Grace
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364936/
https://www.ncbi.nlm.nih.gov/pubmed/22693438
http://dx.doi.org/10.1371/journal.pcbi.1002532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364936/
https://www.ncbi.nlm.nih.gov/pubmed/22693438
http://dx.doi.org/10.1371/journal.pcbi.1002532

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