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General Anesthetics Predicted to Block the GLIC Pore with Micromolar Affinity
Although general anesthetics are known to modulate the activity of ligand-gated ion channels in the Cys-loop superfamily, there is at present neither consensus on the underlying mechanisms, nor predictive models of this modulation. Viable models need to offer quantitative assessment of the relative...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364936/ https://www.ncbi.nlm.nih.gov/pubmed/22693438 http://dx.doi.org/10.1371/journal.pcbi.1002532 |