Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape

Single genome sequencing of early HIV-1 genomes provides a sensitive, dynamic assessment of virus evolution and insight into the earliest anti-viral immune responses in vivo. By using this approach, together with deep sequencing, site-directed mutagenesis, antibody adsorptions and virus-entry assays...

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Detalles Bibliográficos
Autores principales: Bar, Katharine J., Tsao, Chun-yen, Iyer, Shilpa S., Decker, Julie M., Yang, Yongping, Bonsignori, Mattia, Chen, Xi, Hwang, Kwan-Ki, Montefiori, David C., Liao, Hua-Xin, Hraber, Peter, Fischer, William, Li, Hui, Wang, Shuyi, Sterrett, Sarah, Keele, Brandon F., Ganusov, Vitaly V., Perelson, Alan S., Korber, Bette T., Georgiev, Ivelin, McLellan, Jason S., Pavlicek, Jeffrey W., Gao, Feng, Haynes, Barton F., Hahn, Beatrice H., Kwong, Peter D., Shaw, George M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364956/
https://www.ncbi.nlm.nih.gov/pubmed/22693447
http://dx.doi.org/10.1371/journal.ppat.1002721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364956/
https://www.ncbi.nlm.nih.gov/pubmed/22693447
http://dx.doi.org/10.1371/journal.ppat.1002721

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