Lipid Interaction and Membrane Perturbation of Human Islet Amyloid Polypeptide Monomer and Dimer by Molecular Dynamics Simulations

The aggregation of human islet amyloid polypeptide (hIAPP or amylin) is associated with the pathogenesis of type 2 diabetes mellitus. Increasing evidence suggests that the interaction of hIAPP with β-cell membranes plays a crucial role in cytotoxicity. However, the hIAPP-lipid interaction and subseq...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yun, Luo, Yin, Deng, Yonghua, Mu, Yuguang, Wei, Guanghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364971/
https://www.ncbi.nlm.nih.gov/pubmed/22693597
http://dx.doi.org/10.1371/journal.pone.0038191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364971/
https://www.ncbi.nlm.nih.gov/pubmed/22693597
http://dx.doi.org/10.1371/journal.pone.0038191

Ejemplares similares