Genetic Ablation of Nrf2/Antioxidant Response Pathway in Alexander Disease Mice Reduces Hippocampal Gliosis but Does Not Impact Survival

In Alexander disease (AxD) the presence of mutant glial fibrillary acidic protein (GFAP), the major intermediate filament of astrocytes, triggers protein aggregation, with marked induction of a stress response mediated by the transcription factor, Nrf2. To clarify the role of Nrf2 in AxD, we have cr...

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Detalles Bibliográficos
Autores principales: Hagemann, Tracy L., Jobe, Emily M., Messing, Albee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365053/
https://www.ncbi.nlm.nih.gov/pubmed/22693571
http://dx.doi.org/10.1371/journal.pone.0037304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365053/
https://www.ncbi.nlm.nih.gov/pubmed/22693571
http://dx.doi.org/10.1371/journal.pone.0037304

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