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Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting
Tumor and inflammation have many common features. One hallmark of both is enhanced vascular permeability, which is mediated by various factors including bradykinin, nitric oxide (NO), peroxynitrite, prostaglandins etc. A unique characteristic of tumors, however, is defective vascular anatomy. The en...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Japan Academy
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365245/ https://www.ncbi.nlm.nih.gov/pubmed/22450535 http://dx.doi.org/10.2183/pjab.88.53 |