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Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells

Epigenetic treatment concepts have long been ascribed as being tumour-selective. Over the last decade, it has become evident that epigenetic mechanisms are essential for a wide range of intracellular functions in healthy cells as well. Evaluation of possible side-effects and their underlying mechani...

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Detalles Bibliográficos
Autores principales: Purrucker, Jan C., Mahlknecht, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365366/
https://www.ncbi.nlm.nih.gov/pubmed/22704088
http://dx.doi.org/10.1007/s13148-010-0007-1
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author Purrucker, Jan C.
Mahlknecht, Ulrich
author_facet Purrucker, Jan C.
Mahlknecht, Ulrich
author_sort Purrucker, Jan C.
collection PubMed
description Epigenetic treatment concepts have long been ascribed as being tumour-selective. Over the last decade, it has become evident that epigenetic mechanisms are essential for a wide range of intracellular functions in healthy cells as well. Evaluation of possible side-effects and their underlying mechanisms in healthy human cells is necessary in order to improve not only patient safety, but also to support future drug development. Since epigenetic regulation directly interacts with genomic and chromosomal packaging density, increasing genomic instability may be a result subsequent to drug-induced epigenetic modifications. This review highlights past and current research efforts on the influence of epigenetic modification on genomic stability in healthy human cells.
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spelling pubmed-33653662012-06-02 Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells Purrucker, Jan C. Mahlknecht, Ulrich Clin Epigenetics Review Epigenetic treatment concepts have long been ascribed as being tumour-selective. Over the last decade, it has become evident that epigenetic mechanisms are essential for a wide range of intracellular functions in healthy cells as well. Evaluation of possible side-effects and their underlying mechanisms in healthy human cells is necessary in order to improve not only patient safety, but also to support future drug development. Since epigenetic regulation directly interacts with genomic and chromosomal packaging density, increasing genomic instability may be a result subsequent to drug-induced epigenetic modifications. This review highlights past and current research efforts on the influence of epigenetic modification on genomic stability in healthy human cells. Springer-Verlag 2010-07-27 /pmc/articles/PMC3365366/ /pubmed/22704088 http://dx.doi.org/10.1007/s13148-010-0007-1 Text en © Springer-Verlag 2010
spellingShingle Review
Purrucker, Jan C.
Mahlknecht, Ulrich
Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells
title Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells
title_full Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells
title_fullStr Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells
title_full_unstemmed Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells
title_short Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells
title_sort targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365366/
https://www.ncbi.nlm.nih.gov/pubmed/22704088
http://dx.doi.org/10.1007/s13148-010-0007-1
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