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Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications
Epigenetic changes in long interspersed nuclear element-1s (LINE-1s or L1s) occur early during the process of carcinogenesis. A lower methylation level (hypomethylation) of LINE-1 is common in most cancers, and the methylation level is further decreased in more advanced cancers. Consequently, severa...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer-Verlag
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365388/ https://www.ncbi.nlm.nih.gov/pubmed/22704344 http://dx.doi.org/10.1007/s13148-011-0032-8 |