Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1

Continuously dividing cells must be protected from telomeric and nontelomeric DNA damage in order to maintain their proliferative potential. Here, we report a novel telomere-protecting mechanism regulated by nucleostemin (NS). NS depletion increased the number of telomere damage foci in both telomer...

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Detalles Bibliográficos
Autores principales: Hsu, Joseph K., Lin, Tao, Tsai, Robert Y.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365494/
https://www.ncbi.nlm.nih.gov/pubmed/22641345
http://dx.doi.org/10.1083/jcb.201109038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365494/
https://www.ncbi.nlm.nih.gov/pubmed/22641345
http://dx.doi.org/10.1083/jcb.201109038

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