Cargando…
Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1
Continuously dividing cells must be protected from telomeric and nontelomeric DNA damage in order to maintain their proliferative potential. Here, we report a novel telomere-protecting mechanism regulated by nucleostemin (NS). NS depletion increased the number of telomere damage foci in both telomer...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365494/ https://www.ncbi.nlm.nih.gov/pubmed/22641345 http://dx.doi.org/10.1083/jcb.201109038 |