Differential effects of nutritional folic acid deficiency and moderate hyperhomocysteinemia on aortic plaque formation and genome-wide DNA methylation in vascular tissue from ApoE-/- mice

Low folate intake is associated with vascular disease. Causality has been attributed to hyperhomocysteinemia. However, human intervention trials have failed to show the benefit of homocysteine-lowering therapies. Alternatively, low folate may promote vascular disease by deregulating DNA methylation....

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Detalles Bibliográficos
Autores principales: McNeil, Chris J., Beattie, John H., Gordon, M-J, Pirie, Lynn P., Duthie, Susan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365600/
https://www.ncbi.nlm.nih.gov/pubmed/22704348
http://dx.doi.org/10.1007/s13148-011-0022-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365600/
https://www.ncbi.nlm.nih.gov/pubmed/22704348
http://dx.doi.org/10.1007/s13148-011-0022-x

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