A Model-Structure of a Periplasm-facing State of the NhaA Antiporter Suggests the Molecular Underpinnings of pH-induced Conformational Changes

The Escherichia coli NhaA antiporter couples the transport of H(+) and Na(+) (or Li(+)) ions to maintain the proper pH range and Na(+) concentration in cells. A crystal structure of NhaA, solved at pH 4, comprises 12 transmembrane helices (TMs), arranged in two domains, with a large cytoplasm-facing...

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Detalles Bibliográficos
Autores principales: Schushan, Maya, Rimon, Abraham, Haliloglu, Turkan, Forrest, Lucy R., Padan, Etana, Ben-Tal, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365733/
https://www.ncbi.nlm.nih.gov/pubmed/22431724
http://dx.doi.org/10.1074/jbc.M111.336446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365733/
https://www.ncbi.nlm.nih.gov/pubmed/22431724
http://dx.doi.org/10.1074/jbc.M111.336446

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