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A Model-Structure of a Periplasm-facing State of the NhaA Antiporter Suggests the Molecular Underpinnings of pH-induced Conformational Changes

The Escherichia coli NhaA antiporter couples the transport of H(+) and Na(+) (or Li(+)) ions to maintain the proper pH range and Na(+) concentration in cells. A crystal structure of NhaA, solved at pH 4, comprises 12 transmembrane helices (TMs), arranged in two domains, with a large cytoplasm-facing...

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Detalles Bibliográficos
Autores principales:	Schushan, Maya, Rimon, Abraham, Haliloglu, Turkan, Forrest, Lucy R., Padan, Etana, Ben-Tal, Nir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365733/ https://www.ncbi.nlm.nih.gov/pubmed/22431724 http://dx.doi.org/10.1074/jbc.M111.336446

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