The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters

Ibogaine, a hallucinogenic alkaloid proposed as a treatment for opiate withdrawal, has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. Ibogaine binding to SERT increases accessibility in the permeat...

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Detalles Bibliográficos
Autores principales: Bulling, Simon, Schicker, Klaus, Zhang, Yuan-Wei, Steinkellner, Thomas, Stockner, Thomas, Gruber, Christian W., Boehm, Stefan, Freissmuth, Michael, Rudnick, Gary, Sitte, Harald H., Sandtner, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365767/
https://www.ncbi.nlm.nih.gov/pubmed/22451652
http://dx.doi.org/10.1074/jbc.M112.343681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365767/
https://www.ncbi.nlm.nih.gov/pubmed/22451652
http://dx.doi.org/10.1074/jbc.M112.343681

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