Mutation of Conserved Histidines Alters Tertiary Structure and Nanomechanics of Consensus Ankyrin Repeats

The conserved TPLH tetrapeptide motif of ankyrin repeats (ARs) plays an important role in stabilizing AR proteins, and histidine (TPLH)-to-arginine (TPLR) mutations in this motif have been associated with a hereditary human anemia, spherocytosis. Here, we used a combination of atomic force microscop...

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Detalles Bibliográficos
Autores principales: Lee, Whasil, Strümpfer, Johan, Bennett, Vann, Schulten, Klaus, Marszalek, Piotr E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365944/
https://www.ncbi.nlm.nih.gov/pubmed/22514283
http://dx.doi.org/10.1074/jbc.M112.365569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365944/
https://www.ncbi.nlm.nih.gov/pubmed/22514283
http://dx.doi.org/10.1074/jbc.M112.365569

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