MYC Suppresses Cancer Metastasis by Direct Transcriptional Silencing of αv and β3 Integrin Subunits

Over-expression of MYC transforms cells in culture, elicits malignant tumors in experimental animals and is found in many human tumors. We now report the paradoxical finding that this powerful oncogene can also act as a suppressor of cell motility, invasiveness and metastasis. Overexpression of MYC...

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Detalles Bibliográficos
Autores principales: Liu, Hong, Radisky, Derek C., Yang, Dun, Xu, Ren, Radisky, Evette S., Bissell, Mina J., Bishop, J. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366024/
https://www.ncbi.nlm.nih.gov/pubmed/22581054
http://dx.doi.org/10.1038/ncb2491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366024/
https://www.ncbi.nlm.nih.gov/pubmed/22581054
http://dx.doi.org/10.1038/ncb2491

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