Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs

The pro-apoptotic BH3-only protein, BIK, is widely expressed and although many critical functions in developmental or stress-induced death have been ascribed to this protein, mice lacking Bik display no overt abnormalities. It has been postulated that Bik can serve as a tumour suppressor, on the bas...

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Detalles Bibliográficos
Autores principales: Happo, L, Phipson, B, Smyth, G K, Strasser, A, Scott, C L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366076/
https://www.ncbi.nlm.nih.gov/pubmed/22573037
http://dx.doi.org/10.1038/cddis.2012.42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366076/
https://www.ncbi.nlm.nih.gov/pubmed/22573037
http://dx.doi.org/10.1038/cddis.2012.42

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