Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP(+) toxicity: dual roles for ERK1/2

The regulation of mitochondrial quality has emerged as a central issue in neurodegeneration, diabetes, and cancer. We utilized repeated low-dose applications of the complex I inhibitor 1-methyl-4-phenylpyridinium (MPP(+)) over 2 weeks to study cellular responses to chronic mitochondrial stress. Chro...

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Detalles Bibliográficos
Autores principales: Zhu, J H, Gusdon, A M, Cimen, H, Van Houten, B, Koc, E, Chu, C T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366080/
https://www.ncbi.nlm.nih.gov/pubmed/22622131
http://dx.doi.org/10.1038/cddis.2012.46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366080/
https://www.ncbi.nlm.nih.gov/pubmed/22622131
http://dx.doi.org/10.1038/cddis.2012.46

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