Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications

Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities, bone marrow failure, and extreme risk of leukemic transformation. Bone marrow surveillance is an important part of the clinical management of FA and often reveals cytogenetic aberrations. Here, we review bo...

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Detalles Bibliográficos
Autores principales: Meyer, Stefan, Neitzel, Heidemarie, Tönnies, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366199/
https://www.ncbi.nlm.nih.gov/pubmed/22675616
http://dx.doi.org/10.1155/2012/349837
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author Meyer, Stefan
Neitzel, Heidemarie
Tönnies, Holger
author_facet Meyer, Stefan
Neitzel, Heidemarie
Tönnies, Holger
author_sort Meyer, Stefan
collection PubMed
description Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities, bone marrow failure, and extreme risk of leukemic transformation. Bone marrow surveillance is an important part of the clinical management of FA and often reveals cytogenetic aberrations. Here, we review bone marrow findings in FA and discuss the clinical and biological implications of chromosomal aberrations associated with leukemic transformation.
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spelling pubmed-33661992012-06-06 Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications Meyer, Stefan Neitzel, Heidemarie Tönnies, Holger Anemia Review Article Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities, bone marrow failure, and extreme risk of leukemic transformation. Bone marrow surveillance is an important part of the clinical management of FA and often reveals cytogenetic aberrations. Here, we review bone marrow findings in FA and discuss the clinical and biological implications of chromosomal aberrations associated with leukemic transformation. Hindawi Publishing Corporation 2012 2012-05-23 /pmc/articles/PMC3366199/ /pubmed/22675616 http://dx.doi.org/10.1155/2012/349837 Text en Copyright © 2012 Stefan Meyer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Meyer, Stefan
Neitzel, Heidemarie
Tönnies, Holger
Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications
title Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications
title_full Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications
title_fullStr Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications
title_full_unstemmed Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications
title_short Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications
title_sort chromosomal aberrations associated with clonal evolution and leukemic transformation in fanconi anemia: clinical and biological implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366199/
https://www.ncbi.nlm.nih.gov/pubmed/22675616
http://dx.doi.org/10.1155/2012/349837
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