First Total Synthesis of a Naturally Occurring Iodinated 5′-Deoxyxylofuranosyl Marine Nucleoside

4-Amino-7-(5′-deoxy-β-D-xylofuranosyl)-5-iodo-pyrrolo[2,3-d]pyrimidine 1, an unusual naturally occurring marine nucleoside isolated from an ascidan, Diplosoma sp., was synthesized from D-xylose in seven steps with 28% overall yield on 10 g scale. The key step was Vorbrüggen glycosylation of 5-iodo-p...

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Detalles Bibliográficos
Autores principales: Sun, Jianyun, Dou, Yanhui, Ding, Haixin, Yang, Ruchun, Sun, Qi, Xiao, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366680/
https://www.ncbi.nlm.nih.gov/pubmed/22690148
http://dx.doi.org/10.3390/md10040881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366680/
https://www.ncbi.nlm.nih.gov/pubmed/22690148
http://dx.doi.org/10.3390/md10040881

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