Mitochondrial Genome-Knockout Cells Demonstrate a Dual Mechanism of Action for the Electron Transport Complex I Inhibitor Mycothiazole

Mycothiazole, a polyketide metabolite isolated from the marine sponge Cacospongia mycofijiensis, is a potent inhibitor of metabolic activity and mitochondrial electron transport chain complex I in sensitive cells, but other cells are relatively insensitive to the drug. Sensitive cell lines (IC(50) 0...

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Detalles Bibliográficos
Autores principales: Meyer, Kirsten J., Singh, A. Jonathan, Cameron, Alanna, Tan, An S., Leahy, Dora C., O’Sullivan, David, Joshi, Praneta, La Flamme, Anne C., Northcote, Peter T., Berridge, Michael V., Miller, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366682/
https://www.ncbi.nlm.nih.gov/pubmed/22690150
http://dx.doi.org/10.3390/md10040900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366682/
https://www.ncbi.nlm.nih.gov/pubmed/22690150
http://dx.doi.org/10.3390/md10040900

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