Unspliced Precursors of NMD-Sensitive β-Globin Transcripts Exhibit Decreased Steady-State Levels in Erythroid Cells

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that detects and rapidly degrades mRNAs carrying premature translation-termination codons (PTCs). Mammalian NMD depends on both splicing and translation, and requires recognition of the premature stop codon by the cytoplasmic ribosome...

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Detalles Bibliográficos
Autores principales: Morgado, Ana, Almeida, Fátima, Teixeira, Alexandre, Silva, Ana Luísa, Romão, Luísa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366927/
https://www.ncbi.nlm.nih.gov/pubmed/22675570
http://dx.doi.org/10.1371/journal.pone.0038505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366927/
https://www.ncbi.nlm.nih.gov/pubmed/22675570
http://dx.doi.org/10.1371/journal.pone.0038505

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