In Vivo Detection of Amyloid-β Deposits Using Heavy Chain Antibody Fragments in a Transgenic Mouse Model for Alzheimer's Disease

This study investigated the in vivo properties of two heavy chain antibody fragments (V(H)H), ni3A and pa2H, to differentially detect vascular or parenchymal amyloid-β deposits characteristic for Alzheimer's disease and cerebral amyloid angiopathy. Blood clearance and biodistribution including...

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Detalles Bibliográficos
Autores principales: Nabuurs, Rob J. A., Rutgers, Kim S., Welling, Mick M., Metaxas, Athanasios, de Backer, Maaike E., Rotman, Maarten, Bacskai, Brian J., van Buchem, Mark A., van der Maarel, Silvère M., van der Weerd, Louise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366949/
https://www.ncbi.nlm.nih.gov/pubmed/22675537
http://dx.doi.org/10.1371/journal.pone.0038284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366949/
https://www.ncbi.nlm.nih.gov/pubmed/22675537
http://dx.doi.org/10.1371/journal.pone.0038284

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