LSK Derived LSK(–) Cells Have a High Apoptotic Rate Related to Survival Regulation of Hematopoietic and Leukemic Stem Cells

A balanced pool of hematopoietic stem cells (HSCs) in bone marrow is tightly regulated, and this regulation is disturbed in hematopoietic malignancies such as chronic myeloid leukemia (CML). The underlying mechanisms are largely unknown. Here we show that the Lin(−)Sca-1(+)c-Kit(-) (LSK(−)) cell pop...

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Detalles Bibliográficos
Autores principales: Peng, Cong, Chen, Yaoyu, Shan, Yi, Zhang, Haojian, Guo, Zhiru, Li, Dongguang, Li, Shaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366951/
https://www.ncbi.nlm.nih.gov/pubmed/22675576
http://dx.doi.org/10.1371/journal.pone.0038614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366951/
https://www.ncbi.nlm.nih.gov/pubmed/22675576
http://dx.doi.org/10.1371/journal.pone.0038614

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