Force spectroscopy reveals the DNA structural dynamics that govern the slow binding of Actinomycin D

Actinomycin D (ActD) is a small molecule with strong antibiotic and anticancer activity. However, its biologically relevant DNA-binding mechanism has never been resolved, with some studies suggesting that the primary binding mode is intercalation, and others suggesting that single-stranded DNA bindi...

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Detalles Bibliográficos
Autores principales: Paramanathan, Thayaparan, Vladescu, Ioana, McCauley, Micah J., Rouzina, Ioulia, Williams, Mark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367174/
https://www.ncbi.nlm.nih.gov/pubmed/22328730
http://dx.doi.org/10.1093/nar/gks069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367174/
https://www.ncbi.nlm.nih.gov/pubmed/22328730
http://dx.doi.org/10.1093/nar/gks069

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