Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP

Dnmt1 is frequently overexpressed in cancers, which contributes significantly to cancer-associated epigenetic silencing of tumor suppressor genes. However, the mechanism of Dnmt1 overexpression remains elusive. Herein, we elucidate a pathway through which nuclear receptor SHP inhibits zinc-dependent...

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Detalles Bibliográficos
Autores principales: Zhang, Yuxia, Andrews, Glen K., Wang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367194/
https://www.ncbi.nlm.nih.gov/pubmed/22362755
http://dx.doi.org/10.1093/nar/gks159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367194/
https://www.ncbi.nlm.nih.gov/pubmed/22362755
http://dx.doi.org/10.1093/nar/gks159

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