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Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP
Dnmt1 is frequently overexpressed in cancers, which contributes significantly to cancer-associated epigenetic silencing of tumor suppressor genes. However, the mechanism of Dnmt1 overexpression remains elusive. Herein, we elucidate a pathway through which nuclear receptor SHP inhibits zinc-dependent...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367194/ https://www.ncbi.nlm.nih.gov/pubmed/22362755 http://dx.doi.org/10.1093/nar/gks159 |